Thursday, 5 July 2012

Anti-Ageing and Rejuvenation



Life begins at conception and then progresses through the many stages of development, birth, growth, puberty, maturity, old age, disease and finally death. Between Birth and Death a lot happens which determine, how long we live and the quality of life we have.
Why do we die?
                We die for the good of the species. If we live on the fast lane we die young.
                The influence of the genes is associated with the development of chronic
                Diseases resulting in death.
Food, pollution, drugs, oxygen, parasites etc produce free radicals. All molecules have paired arms or electron. A molecule with an unpaired electron is a free radical. They are unstable and will extract electrons from other biological molecules, which generate more free radicals. Ageing is a consequence of an over production of free radicals. Without the body’s free radicals, you would die because they are integral in producing cellular energy from food, defending you against opportunistic infections, and making the hormones needed to maintain communications in your body. It's that unpaired electron that makes free radicals reactive so that they can do their assigned job. These free radicals in the process of wanting to make themselves whole again start to rob electrons from other molecules in turn making them into free radicals. Excess amount of free radicals cause oxidation of fat, proteins and damage to the nucleus of the DNA resulting in accelerating Ageing. 
Telomere is a small segment at the end of nuclear DNA that becomes shorter with every replication of the DNA. DNA will no longer replicate beyond a certain point of the telomere reduction.
CARBOHYDRATES: produces Heat & Energy. It is made up of Carbon, Oxygen & Hydrogen and comes from all starches and Sugars.

Carbohydrates (also referred to as glycans) have the basic composition:
There are two Types of Carbohydrates: 1. Complex Starch.    2. Refined Starch.
Complex Starch which is good for you and a necessary starch which come from all whole grains, potatoes, bread, fruits nuts, green and vegetables. The starches in the green vegetables are stored in their roots, stem and seeds. E.g. Roots like potatoes, beetroot, carrots etc.  Stems like sugar cane, seeds like corn, maize, barley, rye, sago, rice, millet etc.
Complex starches are good for you because they release their sugars slowly, and they are easier to digest.
SUGARS: types of sugars: Lets understand the various types:
Monosaccharides
Glucose, fructose and galactose are all simple sugars, monosaccharides, with the general formula C6H12O6. They have five hydroxyl groups (−OH) and a carbonyl group (C=O) and are cyclic when dissolved in water. They each exist as several isomers with dextro- and laevo-rotatory forms which cause polarized light to diverge to the right or the left.
Glucose, dextrose or grape sugar occurs naturally in fruits and plant juices and is the primary product of photosynthesis. Most ingested carbohydrates are converted into glucose during digestion and it is the form of sugar that is transported round the bodies of animals in the bloodstream. It can be manufactured from starch by the addition of enzymes or in the presence of acids. Glucose syrup is a liquid form of glucose that is widely used in the manufacture of foodstuffs. It can be manufactured from starch by enzymatic hydrolysis.
Fructose or fruit sugar occurs naturally in fruits, some root vegetables, cane sugar and honey and is the sweetest of the sugars. It is one of the components of sucrose or table sugar. It is used as a high fructose syrup which is manufactured from hydrolized corn starch which has been processed to yield corn syrup, with enzymes then added to convert part of the glucose into fructose.
Please be aware today's fructose in most cases is Glorified Corn Syrup. This damaging to the body and is one of the main causes of Obesity and Diabetes.
Galactose does not generally occur in the free state but is a constituent with glucose of the disaccharide lactose or milk sugar. It is less sweet than glucose. It is a component of the antigens found on the surface of red blood cells that determine blood groups.
Disaccharides
Sucrose, maltose and lactose are all compound sugars, disaccharides, with the general formula C12H22O11. They are formed by the combination of two monosaccharide molecules with the exclusion of a molecule of water.
Sucrose is found in the stems of sugar cane and roots of sugar beet. It also occurs naturally alongside fructose and glucose in other plants, particularly fruits and some roots such as carrots. The different proportions of sugars found in these foods determines the range of sweetness experienced when eating the. A molecule of sucrose is formed by the combination of a molecule of glucose with a molecule of fructose. After being eaten, sucrose is split into its constituent parts during digestion by a number of enzymes known assucrases.
Maltose is formed during the germination of certain grains, most notably barley, where it is the source of the malt used in the manufacture of beer. A molecule of maltose is formed by the combination of two molecules of glucose. It is less sweet than glucose, fructose or sucrose.It is formed in the body during the digestion of starch by the enzyme amylase and is itself broken down during digestion by the enzyme maltase.
Lactose is the naturally occurring sugar found in milk. A molecule of lactose is formed by the combination of a molecule of galactose with a molecule of glucose. It is broken down when consumed into its constituent parts by the enzyme lactase during digestion. Children have this enzyme but some adults no longer form it and they are unable to digest lactose.
Production
Sugarcane
Sugarcane (Saccharum spp.) is a perennial grass in the family Poaceae. It is cultivated in tropical and sub-tropical regions for the sucrose that is found in its stems. It requires a frost-free climate with sufficient rainfall during the growing season to make full use of the plant's great growth potential. The crop is harvested mechanically or by hand, chopped into lengths and conveyed rapidly to the processing plant. Here it is either milled and the juice extracted with water or the sugar is extracted by diffusion. The juice is then clarified with lime and heated to kill enzymes. The resulting thin syrup is then concentrated in a series of evaporators and then further water is removed by evaporation in vacuum containers. The resulting supersaturated solution is seeded with sugar crystals and the sugar crystallizes out and is separated from the fluid and dried. Molasses is a by-product of the process and the fibre from the stems, known as bagasse, is burned to provide energy for the boiling of the syrup. The crystals of raw sugar have a sticky brown coating and can either be used as they are or can be bleached by sulphur dioxide or treated in a carbonation process to produce a whiter product.
Sugar beet
Sugar beet (Beta vulgaris) is an annual plant in the family Amaranthaceae, the tuberous root of which contains a high proportion of sucrose. It is cultivated in temperate regions with adequate rainfall and requires a fertile soil. The crop is harvested mechanically in the autumn and the crown of leaves and excess soil removed. The roots do not deteriorate rapidly and may be left in a clamp in the field for some weeks before being transported to the processing plant. Here the crop is washed and sliced and the sugar extracted by diffusion. The raw juice is then treated with lime and carbonated in a number of stages in order to purify it. Water is evaporated by boiling the syrup under a vacuum. The syrup is then cooled and seeded with sugar crystals. The white sugar which crystallizes out can be separated in a centrifuge and dried. It requires no further refining.


Oligosaccharides - a few monosaccharides covalently linked.

Polysaccharides - polymers consisting of chains of monosaccharide or disaccharide units.

Although our body needs starch/carbohydrates to survive and without it the cells can be starved from Insulin resulting in hypoglycaemia and death, in excess it can result in damage to the cell nucleus, the DNA. This can create free radicals and accelerate the aging process and disease.
All Carbohydrates are sugars. When the body senses sugar it releases Insulin and Triglycerides (the so called Bad Cholesterol But you will learn that all Cholesterol is made by the Liver and is needed for the protection of body proper function).

(a) Monosaccharides, which contain dextrose, glucose, fructose and galactose.
(b) Disaccharide’s: starches from cane sugar & sucrose, maltase, malt sugar, & lactose.
(c) Polysaccharides: dextrin, cellulose & glycogen.
Refined Starch comes from all processed foods, such as white flour, pasta made from such grains, sugar, etc.

                               demands the release Insulin
Sugar   <                                                                       = results in Sticky Blood & Constrictors
                               releases Triglycerides / LDL
                                (Bad Cholesterol)
In reality it is wise to realize that there is no Good or Bad Cholesterol. All Cholesterol is made by the Liver and it is produced to assist the body and not damage it. It is only when Man interferes with the body's natural products and processes, that we harm our body and make it unhealthy.
The Equation is,' Fat cuts Fat and Sugar Makes Fat'. 
Your Doctor will advise you otherwise, that is why they have one of the shortest life span. Isn't that enough Proof, that they have it wrong.

How do we know we are ageing? 
Here are some tips to look for they are,

Biological markers of ageing

Markers that increase with age                         Markers that decrease with age
Insulin resistance                                                glucose tolerance
Systolic blood pressure                                      Aerobic capacity
Percent body fat                                                  muscle mass
Lipid ratio       strength, temperature regulation, immune                                                                                                                                                                                                                                                     function,
The more carbohydrates we consume the more demands we make on insulin. When the body produces Insulin the result is an influx of free radicals. Free Radical damage is the number one reason attached to ageing.
A fact to remember is the Glycaemic Index. It is a measure of rate at which a carbohydrate will enter the bloodstream as glucose. Some simple sugars, like table sugar, will enter the bloodstream slower than many complex carbohydrates, such as bread, rice and potatoes. The faster a carbohydrate enters the bloodstream, the higher its Glycaemic index. The higher the Glycaemic index of a carbohydrate, the greater the increase in insulin levels. Fruits & vegetables tend to have a lower Glycaemic index, whereas bread, pasta, grains & starches tend to have a higher glycaemic index.
Sugar and saturated fats make cholesterol and accumulate white fat in the body
Insulin Resistance: according to Wikipedia-' Insulin resistance (IR) is a physiological condition where the natural hormone insulin becomes less effective at lowering blood sugars. The resulting increase in blood glucose may raise levels outside the normal range and cause adverse health effects, depending on dietary conditions.[1] Certain cell types such as fat and muscle cells require insulin to absorb glucose. When these cells fail to respond adequately to circulating insulin, blood glucose levels rise. The liver helps regulate glucose levels by reducing its secretion of glucose in the presence of insulin. This normal reduction in the liver’s glucose production may not occur in people with insulin resistance.[2]
Insulin resistance in muscle and fat cells reduces glucose uptake (and also local storage of glucose as glycogen and triglycerides, respectively), whereas insulin resistance in liver cells results in reduced glycogen synthesis and storage and a failure to suppress glucose production and release into the blood. Insulin resistance normally refers to reduced glucose-lowering effects of insulin. However, other functions of insulin can also be affected. For example, insulin resistance in fat cells reduces the normal effects of insulin on lipids and results in reduced uptake of circulating lipids and increased hydrolysis of stored triglycerides. Increased mobilization of stored lipids in these cells elevates free fatty acids in the blood plasma. Elevated blood fatty-acid concentrations (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic syndrome. If insulin resistance exists, more insulin needs to be secreted by the pancreas. If this compensatory increase does not occur, blood glucose concentrations increase and type 2 diabetes occurs.'

Pillars of ageing


Excess insulin,                                      Increased calorie consumption increased DNA turnover
Excess blood glucose,                         Increased AGE formation, Neural death in VMN*
Excess Free radicals,                            Increased calorie consumption, increased AGE formation
Excess cortisol,                                     Neural death in hippocampus,
Decreased Eicosanoid synthesis
*VMN stands for Ventromedial Nucleus the part of the hypothalamus sensitive to excess glucose.
Laboratory tests with mice and the fruit fly have conclusively proved that a restricted or deprived animal lives longer than when does over fed. Also when a fly’s wings are clipped the animal uses less energy and so lives longer. The reason will be discussed later.
 All carbs turn to sugar and when the body senses sugar it releases insulin. Excess Sugar in the blood stream means extra demand for insulin, the cell can only hold so much sugar and the excess is stored in the body in the best way the body deals can deal with it, and that is Store it in Fats. This is not Cholesterol, its VLDL.( Very Low Density Lipids) this is what clogs up you arteries and   makes your blood sticky, forming in time Clots.
These Clots in time become bigger clots and when they move to the heart is prevents the heart from receiving a constant supply of blood and finally a Heart attack. If the Clot went to the Brain it results in a Stroke and when the Clot hits the Lungs it can cause what we know as a Pulmonary Embolism.  But, before the clots inflict the body , the persons suffers symptoms, which your Doctor may not realize them as warning warning signs.

Benefits of calorie restriction


Increased maximum life span                                              decreased fat accumulation
Increased neurotransmitter receptors                               decreased loss of bone mass
Increased learning ability                                                   decreased blood glucose level
Increased immune system function                                  decreased Insulin levels
Increased Kidney function                                                 decreased cancer
Increased length of female fertility                                    decreased autoimmune diseases
                                                                                                decreased blood lipid level
                                                                                                decreased heart diseases
                                                                                                decreased diabetes

We must take care of feeding the body the proper way. Eating too much or too little can be fatal for longevity.  It is better to consume less in quantity and make sure that you get the adequate amount than to eat bulk and suffer as a result of in       adequate nutrients.  Fats, proteins & proper vitamins and minerals are very necessary for proper biological function
Key function of anti-ageing calorie restriction diet
*              Adequate Protein
*              Adequate Essential Fat
*              Adequate level of Carbohydrates
*              Adequate Vitamins & Minerals
*              Eat small meals throughout the day
*              Have some amounts of protein with every meal
*              Always eat your fruits & Vegetables
*              Take your cod liver oil.

Modern man very rarely suffers starvation yet the world is plagued with Diabetes, Obesity, Heart problems, High cholesterol, Cancers, Arthritis etc. Have we asked the question why?
Let us take some time to understand Diabetes.
Study suggests 'type 3 diabetes'


Scientists say they may have discovered a previously unknown form of diabetes, after finding the brain produces insulin as well as the pancreas.
Unlike other types of diabetes, the form - dubbed type 3 by the US Brown Medical School team - is not thought to affect blood sugar.
Type 3 affects brain insulin levels, and appears to be linked with Alzheimer's disease.
Brain is another source of insulin
                       Age and Ageing  From the BBC
DIABETES:  is a condition in which blood glucose is well controlled. In Type 1 the person makes little or no insulin, where as in Type 2 diabetes the result is due to too little or over production of Insulin production with the inability of the target cell to respond to the insulin, also known as insulin resistant. The body is forgetting how to make use of the hormone & having problems in attaching to the needed receptor.
Excess Insulin, accompanied by Vitamin deficiency amalgamated with fats, proteins and sugar creates plaque, which produces sticky blood & CONSTRICTIONS, in the body.  This causes the Organs, and various parts like the muscles, tendons, arteries, nerves etc to become tensed and constricted. E.g. like in arthritis & arteriosclerosis. The bad fat or plaque that sticks to the wall of the artery results in the production of constrictors with a general raise in blood pressure.
The more carbohydrate we consume the more Insulin is released and the more Constriction is produced within the body.
Carbohydrates like oxygen are essential to the cells of the body, yet every breath we take is killing us. This is because it results in the production of free radicals through the process of oxidation.
Frying, Roasting, Toasting, Grilling, Broiling etc make the sugars and fats combine to create a crispiness which we call AGE (Advanced Glycosylation End products). It is the polymerised end products of protein crossed linked with glucose. AGE tends to adhere to capillaries and arteries increasing the risk of heart disease, blindness and kidney failure. AGEs are best estimated by the levels of glycosylated haemoglobin in the bloodstream.
This also raises the homocysteine* & the HbA1c** levels in the blood resulting in increased LDL & Triglycerides to form the wrong Unfriendly FAT. White Lipids finds its way into the circulatory system, muscles and tissues of the body and the blood stream. When a protein-free radical is formed (and these are more  difficult to make), it can now react with glucose molecules to produce AGE that do thing but stick to things a cause biological damage.
 Vitamin ACE are important antioxidants lots of fruits & vegetables are rich in A&C and adequate levels of fats rich in vitamin E this combination helps us to control free radical formation.
As we age our internal antioxidant enzymes become less active.  Couple that with a decrease in the consumption of diet-derived antioxidants leads to accelerated ageing.
When we eat the calories we consume are converted into energy to be used by the body. This energy molecule is ATP. It Adenosine Triphosphate is the primary fuel used by the cells to generate the biochemical reactions essential for life. To form ATP from food requires the breakdown of oxygen to form free radicals in cells. This process is carried out in the mitochondria, which is the cell factory where ATP is generated. The more we eat the more free radicals are produced the damage to the DNA and the faster we age. The other generator of free radicals is the immune system. The best way of defending the body from foreign invaders is to blast them with a burst of free radicals. This is the how the white blood cells work.
The mitochondria DNA derived from your mother and as a consequence your longevity, physical strengths and weaknesses are a direct reflection of your mother and her family.
When the nuclear DNA is damaged by the free radicals it can be repaired; but the mitochondrial DNA does not have the repair system that replaces damaged parts of genetic material. Mitochondrial DNA codes for 13 separate proteins that are critical in ATP production. As we age the mitochondria is less efficient in making ATP. This uncoupling process by the mitochondria becomes less effective and more free radicals are produced, with less ATP meaning less energy & more damage taking place resulting in accelerated ageing.
ATP formation in mammalian mitochondria takes place by a complicated electron transport pathway. An outer and inner membrane largely defines the structure of the mitochondria. The inner mitochondria membrane is where you find all of these components of the electron transport pathway.
Electrons generated by the dehydrogenation of NADH or succinate are transferred from one complex to another until they reach complex IV, also known as cytochrome oxidase. (The high energy NADH comes from the TCA cycle and glycolysis, which in other words means from the processed food that we eat.) Here, the electrons are used to reduce oxygen into to water. ATP is produced as a result of the passage of electrons through complexes I, III, and IV.
ATP production in plants is quite different. Plants have chloroplasts, which you can think of as being like mitochondria in mammals. These chloroplasts use chlorophyll to catalyse photosynthesis, which ultimately does the following two reactions:
The high energy NADPH gets used in other metabolic pathways. The oxygen gets released, to be breathed in by mammals for their own ATP formation. Finally, the extra protons build up in chloroplast organs called thykaloids and make a proton gradient. An ATP synthase, which operates without any light, then couples the flow of protons to ATP synthesis.
When I say coupled, I mean that the enzyme somehow makes it so that for every three protons, which flow out of the thykaloid, one molecule of ATP gets made.
By the way, this is a great example of the inherent energy available in a concentration gradient, which can be converted, in chemical energy used in life.
You can read more about both of these processes in just about any college Biochemistry textbook. I hope that answers your question!
what genes are contained in the mitrochondria and what diseases can arise
The mitochondrial genome (mtDNA) in humans is contained on a single circular chromosome 16,569 basepairs around, and each mitochondrion contains 5 to 10 copies of the mitochondrial chromosome. There are several essential genes in mtDNA that are involved in replication and translation, along with some genes that are crucial for the machinery that converts metabolic energy into ATP. These include NADH dehydrogenase, cytochrome c oxidase, ubiquinol/cytochrome c oxidoreductase, and ATP synthase, as well as the genes for unique Ribosomal RNA and Transfer RNA particles which are required for translating these genes into proteins.
There are specific diseases associated with mutations in some of these genes. Below are the most commonly affected genes and the diseases arising from their mutation.
NADH dehydrogenase:
Severe progressive tubulointerstitial nephritis, a kidney disease that can lead to renal failure, has shown the presence of distorted mitochondria, resulting from a point mutation in ND2 gene. Leber's hereditary optic neuropathy, LHON, arises from mitochondrial DNA mutations in the ND1 and ND4 genes (and in some cases the ubiquinol gene). Eight of these mutations frequently associated with LHON, have also been found in patients with Multiple Sclerosis.
ATP synthase:
Myoclonic Epilepsy and Ragged Red Fiber disease, MERRF, involves mutation of the ATPase 8 gene. While Neurogenic muscle weakness, Ataxia, and Retinitis Pigmentosum, NARP, results from mutations in the ATPase 6 gene.
Transfer RNA genes:
Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike symptoms, MELAS, and Maternally inherited Myopathy and Cardiomyopathy MMC, are caused by different mutation in the gene for the tRNA responsible for adding the amino acid Leucine to mitochondrial proteins.
Large deletions:
Pearson's marrow/pancreas syndrome is one of a few disease associated with a large deletion in the mtDNA. The various tissues of each patient contain populations of both wild-type and deleted mtDNA molecules, suggesting that this disease arises from ongoing damage to the mtDNA, rather than an inherited mutation. Because of the varied population, the clinical expression of Pearson's syndrome is variable and is not correlated with the size and position of the mtDNA deletion.
Molecular Biology of the Cell by Bruce Alberts, et al. - 3rd ed., Garland Publishing, Inc., New York & London, 1995.
An Introduction to Genetic Analysis by Anthony J.F. Griffiths, et al. - 5th ed., W.H. Freeman and Company, New York, 1993.
or search this site for "Mitochondria".
 (*ATP is the energy molecule that converts food into energy. This process is carried out in the mitochondria and requires oxygen. Oxygen produces free radicals and they in turn damage the mitochondria causing ageing. Although we need food the act of metabolising food is damaging. So the more we eat the faster we age. )

FATS - the BRAIN FOOD

We know that a very large amount of our brain is omega fats. According to eastern medicine the extension of the brain is the bone marrow. Here the body makes the white & red blood cells and it plays a very important role in our body’s defences.
Every body is talking about their new diet. The Low Fat diets. Let me tell you Fats are an essential part of our diet. There are good Friendly Fats and there are the unfriendly fats.
I can confirm that this misunderstanding almost cost me my life. Yet without the experience I would not have learnt what I now know. Many have not been as lucky as I to survive the Heart attack I had 10 years ago have.
Very low fat in the short term increases triglyceride levels and decrease HDL, without yielding additional decrease in LDL cholesterol levels.
For certain persons, i.e. those with hyper-triglyceridema or hyper-insulinemia, the elderly, or the very young, the potential for elevated triglycerides, decreased HDL cholesterol levels, or nutrient inadequacy must be considered.
Because very low fat diets represents a radical departure from current prudent dietary guidelines, such diets must be proved both advantageous and safe before national recommendations can be issued.  
Fats consist of glycerol and fatty acids that are made up of carbon & hydrogen.
There are two types of Fats: (1) Saturated (2) Unsaturated.
Saturated fats come from Animal, coconut & Palm oils etc. As a general rule any fat that does not melt in the Palm of your hand is a saturated fat including those that come from plants.
Unsaturated fats are the Omega 3 & 6. They are the friendly fats and create HDL.
Omega comes from oily Fish/ and fish oils, Polyunsaturated essential fat found in cold-water fish and purified fish oils. This oil is beneficial to the cardiovascular system because it promotes the production of ‘Good’ eicosanoids. They also aid in producing long-chain fatty acids like EPA.
Omega 6 comes from Vegetables, Seeds & Nuts. (It is recommended that the Cold Pressed or Extra Virgin oils are the best)  As a general rule Oils from Vegetables & Seeds are Polyunsaturated Fats, whereas oils from the Nut family is Monounsaturated Fats.
Omega 6 fatty acids found in the protein of most oils from seeds and nuts can produce both ‘Good’ & ‘Bad’ eicosanoids
Good eicosanoids are best produced by a combination of omega 3 & 6 oils on a 1:1 ratio. 
Here is an extract on Omega 3 made by Dr. Barry Sears.
Fish Oil & omega-3 Fatty Acids
  Dr. Sears is a research scientist and he created the world famous Zone Diet. His new ground breaking book is called "The Omega Rx Zone - The Miracle of the New High-Dose Fish Oil". It is the culmination of 20 years of research on the benefits of long-chain omega-3 fatty acids contained in omega-3 fish oils. In fact, Dr. Sears pioneered the development of pharmaceutical grade fish oil using the brand name OmegaRx, a highly refined nutritional supplement rich in the omega-3 fatty acids DHA and EPA.  
 History has shown and scientists have found that the Eskimos of Greenland have suffered very little from coronary heart disease despite a diet very high in fat. The primary source of fat in their diet came from sea mammals, which contain large amounts of long-chain omega-3 fatty acids. Dr. Barry Sears OmegaRx Fish Oil contains these same essential omega-3 fatty acids.  
 The American Heart Association recommends healthy people eat omega-3 fatty acids from fish and plant sources to protect their heart.  
 The role of essential fatty acids in the body and mind has been extensively studied. The body of knowledge consists of thousands of scientific studies, including hundreds of clinical studies on omega-3 fatty acids.  
 OmegaRx Pharmaceutical Grade Fish Oil is Twice as Potent and 100's Times More Pure than Health Food Grade Fish Oil. As Dr. Sears explains, the fish oils doled out by our grandmothers and currently sold at health-food stores has never been pure enough to be used in the quantities it takes to feel its potential benefits. The new highly purified Omega Rx pharmaceutical grade fish oil is more concentrated, free of dangerous toxins, and has been clinically tested with encouraging results.
EICOSANOIDS come from the Greek language eicosa, which means 20. Eicosanoids are hormones derived from a 20-carbon atom, polyunsaturated fat. They are made in the cells of the body and are an autocrine hormone. The‘ Good’ eicosanoids generate the cycle AMP.
AMP cycle is a second messenger that begins the biological response started by a hormone. Cycle AMP is used by many endocrine hormones as a second messenger.
Taken on a Ratio of 1:1 they cut fat and create Cholesterol HDL. (The Good Guys).
We need cholesterol for proper function of the body. The Liver produces 80% of the cholesterol. Why? If this is true then do you think that it is right for you to block this natural process?
When your hands get greasy you use soap to wash it away. Grease is Fat and so is soap made from Fat. One density lipids neutralising the other fat or lipid.
Similarly HDL washes away LDL & Tg. This is what happens in the body with the omega 3&6 oils.
These Omega Oils also counteract the effects of the carbohydrate and also create a more relaxed state within known as DILATORS.
When your body is tight and painful it is due to the constrictors. What you need to remedy this syndrome is the friendly Fats to produce the DILATORS.
EFA are Essential Fatty Acids, which the body cannot make and are therefore necessary to be taken regularly in the diet. EFA are the building blocks of eicosanoids. There are two groups Omega 3 and Omega 6 fatty acids.
Fats also produce good Eicosanoids and Glucagons. They are hormones the body needs to metabolise and deal with the fats and sugars.
The job of Insulin is to lower the body sugars. Glucagons raise them by releasing the stored Glycogen from the liver and the Eicosanoids.
Glucagons are a hormone from the pancreas that causes the release of stored carbohydrates in the liver to restore blood glucose levels. They use the second messenger cycle AMP, to exert its biological action.
There is enough research to indicate that Niacin or B3 100mg taken with each meal will reduce your blood cholesterol. The findings are that is works even better than the cholesterol lowering drugs e.g. Staten; but when taken alongside Staten the combination works the best.
When you take Niacin you will experience a hot flush about 15-min later which can last for about 10-15min. This is indicating that the B3 is being metabolised by the liver and changing it to NIACINEMIDE. So don’t panic, rejoice and you are aware that the Niacin is working.

Glucagons

A hormone responsible for helping maintain proper sugar levels. When blood sugar levels go too low glucagons activate glucose production in the liver as well as regulate the release of glycogen from muscle cells. Eventually it may cause the catabolism of muscle cell protein for glucose. This is considered a catabolic hormone. It therefore acts somewhat similar to the carburettor in the engine in your car. When properly tuned it causes the engine to give you better performance and more miles per gallon. The same is true of the Glucagons in your body. It helps the release of stored glucose and delays the hunger feeling till it has used up all the fuel from the carbohydrates. This is what diabetics need greatly. Although we need carbohydrates to fuel the body we need very little of it to run its engines.
Life is not complete without exercise.
In nature: Carbon dioxide + Water give birth to Life & Plants which supply us with Oxygen & Glucose.
This gives us the food and energy we need to perform Aerobic exercise to burn off the calories and return to nature the Carbon dioxide + water needed to complete the cycle.
Although we need oxygen to survive, like the carbohydrates we need little of it. As explained earlier, carbohydrates demand insulin for its digestion and produces Free Radicals & Constriction in the process.  So to does Oxygen produces Free Radicals and accelerates ageing.
Friendly Omega 3&6 produce Good Eicosanoids & Glucagons = Dilators so to the release of Carbon Dioxide in the blood encourages proper function of the body and Dilators. As everyone breathes at an average of 21600 rhythms in 24 hours- which is 900 an hour, 15 a minute and one breathe every 4 seconds. This gives us a life span of 70 years (3 score years & 10).  Every breath saved goes to prolong long life. If you breathe slowly, deeply and rhythmically this is a recipe for long life.
The Air we breath is 20% oxygen & 80 % Nitrogen. Oxygen breaks up into its oxides, which produces the free radicals that destroy the nucleus of the Cell the DNA.
On the other hand nitrogen breaks up into its oxides known as NITRIC OXIDE: In 1987 Nitric oxide was discovered. It is one of the smallest molecule and is a free radical to boot. This reactive free radical provides the latest clue on the power of the diet to alter hormonal response.  It is the hormone that needs no receptor. It travels a short distance and is self distrusted; a component of Air Pollution and cigarette smoke, it controls cardiovascular, immune and nervous system. It is also the key to erectile problems. Nitrogen free radical=nitric oxide.
Unlike oxygen free radicals nitric oxide is relatively stable. It is possible to maintain nitric oxide in a gaseous form for more than 40 years. Nitric oxide is an interesting carrier of information.
Breathe slowly and hold for a while, then breathe out and hold for a while. Try to prolong the hold comfortable for as long as possible.  The oxygen is used up and carbon dioxide is released to produce dilators. The nitrogen is then broken down into its oxides = nitric oxide which produces the same as end products as GTN or TNT. It is what is used when you suffer angina. This can also produce Argentine, which has the same effect as Viagra.
PROTEINS - make good NEUROTRANSMITTERS 
Proteins:  Low fat proteins are the best. Some of the foods below are complete proteins.
Organic Soya and fish products top the list. ***
Organic eggs, especially the white, are next **
Lean meats, poultry, and dairy products next. *
Pulses, legumes, peas etc., are incomplete proteins; but when combined with a complete protein it makes an excellent substitute. (It is well to remember that legumes and gluten produce the most lectins*)
Proteins serve to give us the amino acids we need.
Fruits and vegetables serve to give us the essential vitamins and minerals we need; but it is essential that the best choice is from Organic foods as they are usually found to contain the best and highest amounts of the above.
Adequate Proteins, Essential Fatty Acids, carbohydrates & vitamins and minerals, fluids, exercises are important.
The general recommendation is as follows:
Lower Glycaemia carbohydrate intake along with a raised Essential Fats (the omega 3& 6 oils), and selected proteins.
My observation of nature shows me that all vegetarian animals eat from dawn to dusk. They are strong, heavy and generally fat. Their coat and skin is rough, they have dull vision slow in motion and generally taken advantage of. We as a rule do not have them as pets.
Carnivores or meat eating animals eat once a day and less frequently. They have a lot of stamina, slim and fast in motion. There skin and coat is fine and smooth and their eyes are clear and vision sharp. We generally keep them, as pets.
Proteins and fats cut fat and keep us slim. Carbohydrates make sugar and fat, resulting in sticky blood, diabetes and heart conditions. If we believe in evolution then we become aware that marine life came before terrestrial plants.
Make up your own mind whether you want to be a grazer or a layer. A pet or a worker. Be admired and beautiful or heavy & bullied. 
·         For those who are Vegetarians please note: you must have Proteins from plant, seed, nuts & legumes. But not all these proteins are helpful. You must have the ones compatible with your blood group. Protein incompatible with your blood group produces Bad Lectins*. If however you can have fish & eggs to your diet, it will be an added bonus.
·         Re Fish Oils It must also be noted that though there are many claims of plant based EPA  in reality there is no known true long chain EPA derived from plant oils.

                                                                Anti-Wrinkle Spray

AntiAge-Rejuvenate

What is AGE? What is Ageing? Is it possible to slow down ageing? Is it possible to Rejuvenate? In this Blog we will discuss these issues